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In vitro studies indicate that hepatic resident macrophages detect elevated free fatty acids and respond by increasing TNF- secretion that, in turn, promotes the progression of steatosis in hepatocytes ( Metabolic burden in hepatocytes activates multiple cell death pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, which can further amplify the inflammatory and fibrogenic response ( Figure 1B )

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Simultaneous targeting of differentiated breast cancer cells and breast cancer stem cells by combination of docetaxel- and sulforaphane-loaded self-assembled poly(D, L-lactide-co-glycolide)/hyaluronic acid block copolymer-based nanoparticles

However, these observations may not be exclusive to acute exacerbations of AD but could instead reflect general changes seen in inflammatory or infectious disorders (65)